@mattgundersen, for scanning, have you seen the code in this topic?
I don’t see any reason why the AM2315 should not work. Have you tried having ONLY the AM2315 on the I2C bus? You are pulling up th 5V or 3.3V? Do you have a logic analyzer by any chance?
When you say it does not respond to the wake command, how did you observe that? Can you give more details? 